Many photovoltaic (PV) manufacturers use processes and equipment similar to that of the microelectronics industry although there is a variation in the wet processes as well as substrates and end-products. Due to this, there is little guidance on the performances and design standards of process water and wastewater treatment systems. This article examines water and wastewater challenges specific to PV manufacturing and how lower facility costs coupled with greater sustainability can be achieved through approaching design aspects.